Learning Objectives for "Viral Activation of Immune Responses"

After completing this section you should be able to perform the following objectives.

1*. Compare and contrast innate immunity and adaptive immunity.

2*. Describe how type I interferons produced during innate immunity function as an antiviral defense in the body.

3*. Define antigen and epitope.

4*. Define humoral immunity and cell-mediated immunity.

5*. Briefly describe how opsonizing antibodies can promote phagocytosis of viruses and how antibodies made against viral surface antigens can block adsorption of viruses to host cell receptors.

6.* In terms of the role of cytotoxic T-lymphocytes (CTLs) in body defense:

a. Describe how they can react with and destroy virus-infected cells, cells containing intracellular bacteria, and cancer cells. (Indicate the role of following: TCR, CD4, MHC-I, and peptides from viral antigens.)

b. State the mechanism by which cytotoxic T-lymphocytes kill the cells to which they bind.

(*) = Common theme throughout the course (**) = More depth and common theme

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